CYR61 Antibody  AP50797  100ug

CYR61 Antibody - Product
infoApplication WBP
Reactivity  Human
Concentration 1mg/ml
Calculated MW 42KD

Other Names
Protein CYR61, CCN family member 1, Cysteine-rich angiogenic inducer 61, Insulin-like growth factor-binding protein 10, IBP-10, IGF-binding protein 10, IGFBP-10, Protein GIG1, CYR61, CCN1, GIG1, IGFBP10
Dilution
WB~~ 1:1000
Format
Immunogen affinity purified.Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.
Storage
Store at -20 °C.Stable for 12 months from date of receipt

CYR61 Antibody - Protein Information
Name CYR61
Synonyms CCN1, GIG1, IGFBP10
Function
Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.
Cellular Location
Secreted.