Anti-Mouse CD38 FITC

11-0381-81

50ug

The 90 monoclonal antibody reacts with the mouse CD38 molecule, an ~42kDa type II transmembrane

protein. CD38 is expressed at increasingly higher levels on B cells ateach stage of B-cell
differentiation, and is then down-regulated on germinal center B cellsand mature plasma cells.
Its expression is reported on a subpopulation of thymocytes, mature Tcells, and NK cells.
Crosslinking of CD38 on the surface of mature, resting B cells inducesB-cell proliferation,
which is enhanced by co-signals such as IL-4 and LPS. CD38, acounter-receptor for CD31, is
an ectoenzyme with cyclase and hydrolase enzymatic activity and isspeculated to play a role
in lymphocyte activation and differentiation.