Anti-Mouse CD21/CD35 FITC

11-0212-81
50ug

USA

The monoclonal antibody eBio4E3 reacts with an eptiope shared by mouseCD21 (CR2) and CD35 (CR1).

CD21 and CD35 are alternatively spliced transcripts from the Cr2 gene,which result in cell-surface
proteins of 145 and 190 kDa, respectively. CD21 and CD35 are expressedby mature B cells, but not
on thymocytes, peripheral T cells, erythrocytes or platelets.Furthermore, there is little
evidence which demonstrates their expression on macrophages. CD21 is areceptor for
complement component C3d and Epstein-Barr virus (EBV), and inassociation with CD19
and CD81, CD21 also participates in B-cell activation through the Bcell receptor.
Cr2 deficient mice display impaired inflammatory and humoral immuneresponses in vivo.
The anti-mouse CD21/35 monoclonal antibody clones eBio4E3 and eBio8D9do not cross-block
each other suggesting that they bind to different epitopes.