Anti-Mouse CD21/CD35 FITC

11-0211-82
100ug

USA

The monoclonal antibody eBio8D9 reacts with an eptiope shared by

mouse CD21 (CR2) and CD35 (CR1). CD21 and CD35 are alternativelyspliced transcripts
from the Cr2 gene, which produce cell-surface proteins of 145 and 190 kDa, respectively.
CD21 and CD35 are expressed by mature B cells, but not on thymocytes,peripheral T cells,
erythrocytes or platelets. Furthermore, there is some evidence whichdemonstrates their
expression on macrophages. CD21 is a receptor for the complementcomponent C3d and
Epstein-Barr virus (EBV). In association with CD19 and CD81, CD21 also participates
in B-cell activation through the B cell receptor. Cr2-deficient mice display impaired
inflammatory and humoral immune responses in vivo.

The anti-mouse CD21/35 monoclonal antibody clones eBio4E3 and eBio8D9do not cross-block
each other, suggesting that they bind to different epitopes.