Anti-Human CD10 FITC

11-0106-41

25tests

USA

The eBioCB-CALLA monoclonal antibody recognizes human CD10 (CALLA, NEP,enkephalinase, Neprilysin), which is a 100 kDa, type II cell surface glycoproteinoriginally identified for its expression on most acute lymphoblasticleukemias (ALL).Subsequently, CD10 was shown to be the same molecule as the neutralendopeptidase (NEP),or KII-NA. CD10 is a Zn2+-dependent metallo-peptidase with endothelin,glucagon, gastrin,neurotensin and bradykinin included among its substrates. CD10 isinvolved in the regulationof chemotactic and inflammatory processes involving neutrophils. In Bcells, CD10 regulatesstromal cell-dependent B lymphopoiesis and expression has also beenreported on mature Bcells in germinal centres. In addition to the hematopoieticcompartment, other major sitesof CD10 expression are the brush border of enterocytes and renaltubules and glomeruli.There is partial blocking of the eBioCB-CALLA and MEM-78 monoclonalantibodies indicating