Anti-Rat CD8b FITC

11-0080-81

50ug

USA

The eBio341 monoclonal antibody reacts with rat CD8β. CD8β is a memberof the

immunoglobulin superfamily which heterodimerizes with CD8α to form the CD8
antigen expressed on CD4+CD8+, double-positive thymocytes, the majorityof MHC class
I-restricted peripheral T cells, and on some macrophages. CD8βexpression is
absent in athymic mice, which are populated by T-cells expressing CD8α homodimers.
This has led to the idea that CD8β expression is dependent on thedevelopment of T
cells in the thymus. CD8 binds to MHC class I expressed on the surfaceof antigen-presenting
cells during antigen presentation, and participates in T-cell receptorsignal transduction
through association with the kinase Lck.