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Human NOGGIN
货 号：120-10C
产品规格：5ug
原 产 地：USA
参考价格：960 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Human NOGGIN 120-10C
描述:
Noggin
belongs to a group of diffusible proteins which bind to ligands of the
TGF-β family and regulate their activity by inhibiting their access to
signaling receptors. The interplay between TGF-β ligands and their
natural antagonists has major biological significance during development
processes, in which cellular response can vary considerably depending
upon the local concentration of the signaling molecule. Noggin was
originally identified as a BMP-4 antagonist whose action is critical for
proper formation of the head and other dorsal structures.
Consequently, Noggin has been shown to modulate the activities of other
BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in
mice results in prenatal death and recessive phenotype displaying a
severely malformed skeletal system. Conversely, transgenic mice
over-expressing Noggin in mature osteoblasts display impaired
osteoblastic differentiation, reduced bone formation, and severe
osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked
homodimer (120-10C) consisting of two 206 amino acid polypeptide chains.
Monomeric glycosylated Noggin migrates at an apparent molecular weight
of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing
conditions.
氨基酸序列:
QHYLHIRPAP
SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG
AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV
LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW
IPIQYPIISE CKCSC
来源:
HEK293 cells
纯度:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
生物活性:
Determined
by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline
phosphatase production by ATDC chondrogenic cells. The expected ED50 for this effect is 2.0-3.0 ng/ml of Noggin.