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Murine GDNF
货 号：450-44
产品规格：10ug
原 产 地：USA
参考价格：2340 （参考价格，以实际价格为准）
优惠价格：
产品详细信息
Murine GDNF 450-44
别名:
Glial-Derived Neurotrophic Factor, ATF-1
描述:
GDNF
is a disulfide-linked homodimeric neurotrophic factor structurally
related to Artemin, Neurturin and Persephin. These proteins belong to
the cysteine-knot superfamily of growth factors that assume stable
dimeric protein structures. GDNF signals through a multicomponent
receptor system, composed of a RET and one of the four GFR α(α1-α4)
receptors. GDNF specifically promotes dopamine uptake and survival and
morphological differentiation of midbrain neurons. Using Parkinson’s
disease mouse model, GDNF has been shown to improve conditions such as
bradykinesia, rigidity, and postural instability. The functional murine
GDNF ligand is a disulfide-linked homodimer, of two 15.1 kDa
polypeptide chains called monomers. Each monomer contains seven
conserved cysteine residues, one of which is used for inter-chain
disulfide bridging and the others are involved in intramolecular ring
formation known as the cysteine knot configuration.
氨基酸序列:
MSPDKQAAAL
PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS
GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 was determined by the proliferation of rat C6 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.