Anti-Human CD22 FITC

11-0229-41
25tests

USA

The eBio4KB128 monoclonal antibody recognizes human CD22 (Siglec-2),which is a member

of the siglec subgroup of the Ig superfamily. CD22 is a type Itransmembrane glycoprotein
composed of two polypeptide chains, CD22α and CD22β, of 130 and 140 kDa respectively,
produced by alternative splicing of the CD22 gene. CD22 is expressed athigh levels on
mature B cells and B cell lymphomas. The extracellular portion of CD22contains seven
Ig-like domains, some of which are capable of binding ligands withsialic acid moieties
expressed on epithelial, endothelial, B and T cells. The intracellularportion of CD22
contains 6 tyrosine residues contained within immunotyrosine-basedinhibitory motifs (ITIM) and
immunotyrosine-based activation-like motifs, which are phosphorylatedupon B-cell receptor
engagement, which enables CD22 to participate in the positive andnegative regulation of
B-cell receptor signaling.