Anti-Mouse CD3e FITC

11-0031-86
 1MG
USA

The 145-2C11 monoclonal antibody reacts with mouse CD3e, a 20 kDa subunit

of the TCR complex. Along with the other CD3 subunits, gamma and delta,
the epsilon chain is required for proper assembly, trafficking and surface
expression of the TCR complex. CD3 is expressed by thymocytes in a
developmentally regulated manner and by all mature T cells. Binding
of 145-2C11 to TCR initiates the intracellular biochemical pathway
resulting in cellular activation, proliferation, and apoptosis depending
on specific conditions utilized. 145-2C11 is commonly used as aphenotypic marker for mouse T cells.